翻訳と辞書
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・ Transcription (software)
・ Transcription activator-like effector nuclease
・ Transcription Broadcast Systems
・ Transcription bubble
・ Transcription coregulator
・ Transcription disc
・ Transcription elongation regulator 1
・ Transcription error
・ Transcription factor
・ Transcription factor DP
・ Transcription factor II A
・ Transcription factor II B
・ Transcription factor II D
・ Transcription factor II E
・ Transcription factor II F
Transcription factor II H
・ Transcription factor IIIB 50 kDa subunit
・ Transcription factories
・ Transcription initiation protein SPT3 homolog
・ Transcription into Chinese characters
・ Transcription into Japanese
・ Transcription machine
・ Transcription of Australian Aboriginal languages
・ Transcription of Russian
・ Transcription preinitiation complex
・ Transcription termination factor, RNA polymerase I
・ Transcription-mediated amplification
・ Transcriptional activator LAG-3
・ Transcriptional bursting
・ Transcriptional noise


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Transcription factor II H : ウィキペディア英語版
Transcription factor II H

Transcription factor II Human (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH consists of ten subunits, 7 of which (XPD, XPB, p62, p52, p44, p34 and TTDA) form the core complex. The cyclin activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or if it is supercoiled.
Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle. Next to a vital function in transcription initiation, TFIIH is also involved in nucleotide excision repair.
It is responsible for giving the 'go' signal which is why it is assembled last.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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